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. 2022 Oct 2;30(1):641–651. doi: 10.1245/s10434-022-12532-x

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Analysis of cMBP-ICG dosage selection in vivo and ex vivo after fluorescence imaging, and correlation between c-MET expression and cMBP-ICG signal intensity. A Snapshots of two patients from different dosage groups. The MFI and TBR of each group and each application procedure (in vivo/ex vivo) were calculated following the same process. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. Data are presented as mean ± SEM. B Representative c-MET immunohistochemistry images and hematoxylin and eosin images from a paraffin-embedded tumor section of a patient (slide overview) showing an area of head and neck squamous cell carcinoma (SCC) (black circle). Preoperative in vivo cMBP-ICG imaging of the patient showing the slide location in the whole tumor. C Immunofluorescence of the paraffin-embedded tumor shown in panel B. cMBP-ICG, c-MET-binding peptide-indocyanine green; MFI, mean fluorescence intensity; TBR, tumor-to-background ratio; SEM, standard error of the mean