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. 2022 Oct 2;30(1):641–651. doi: 10.1245/s10434-022-12532-x

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Comparison of epithelial neoplasia and two grades of head and neck squamous cell carcinoma (SCC). A Epithelial neoplasia showing low fluorescence intensity (FI) in both in vivo and ex vivo imaging. The frozen section shows low c-MET expression of this lesion. B Highly differentiated head and neck SCC showing slightly increased FI compared with panel A. The frozen section shows about 25% of the c-MET expression area fraction. C Moderately differentiated head and neck SCC showing high FI in in vivo and ex vivo imaging. The frozen section shows about 90% of the c-MET expression area fraction