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(A) Stability of compound 5b in PBS (pH 5.5 and pH 7.4) and plasma. (B) The body weight of the mice during the treatment. (C) Tumor growth of HCT116 model inhibited by 5b (**p < 0.01; ***p < 0.001). (D) Represented weight of tumors from mice of different groups, respectively. Data were mean ± S.D. (n = 5, *p < 0.05). (E) Representative photographs of subcutaneous tumors in the HCT116 model.
