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Antiproliferative activity of compounds 5a, 5b, and 5c.
| Cell lines | IC50 (μM) | |||
|---|---|---|---|---|
| 5a | 5b | 5c | Irinotecan | |
| HCT116 | 0.042 ± 0.04 | 0.045 ± 0.02 | 0.044 ± 0.02 | 5.15 ± 1.3 |
| DLD1 | 6.08 ± 0.34 | 6.66 ± 0.42 | 6.16 ± 2.48 | 30.29 ± 3 |
| HT29 | 2.18 ± 0.17 | 1.95 ± 0.07 | 2.05 ± 0.26 | 42.70 ± 2.01 |
