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. 2022 Oct 10;127(12):2141–2153. doi: 10.1038/s41416-022-02006-y

Fig. 1. FGF14-AS2 suppresses breast cancer osteolytic metastasis.

Fig. 1

a FGF14-AS2-overexpressing MDA-MB-231 cells (OE-FGF14-AS2) and control cells (OEC) were injected into the tibiae of female nude mice. n = 5 for each group. b Representative micro-CT images of bone lesions in mice from each group (left panel) and quantitative analyses (right panel). c Representative images of H&E staining of the tibia sections. d Representative images of TRAP staining of the tibiae. e Schematic diagram of osteoclast differentiation of induced RAW264.7 cells. f RAW264.7 cells were stimulated with the indicated conditioned medium (CM) in the presence of RANKL (50 ng/mL). Cells were fixed and stained for TRAP activity (left panel), and the areas of TRAP-positive cells (multinucleated cells) were analysed (right panel). Scale bar = 200 µm. The data are shown as the mean ± s.d. of at least three independent experiments. **P < 0.005, ***P < 0.001.