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. 2022 Oct 19;127(12):2207–2219. doi: 10.1038/s41416-022-02011-1

Fig. 5. In vivo anti-tumour efficacy of mTOR siRNA-loaded neutral liposome in DMBA-induced breast tumour model in SD rats.

Fig. 5

a Alteration in tumour volume of cancer-bearing mice following treatment with NL-C-siRNA and NL-mTOR-siRNA. b Images of tumours of each group excised after the end of the treatment protocol. c Photomicrographic depiction of breast tissues isolated from different experimental groups as analysed by FESEM to determine the structural and morphological alterations. d Histopathological evaluation (×400) of breast tissues obtained from different groups of experimental animals, where scale bar represent 50 µm section. Normal control: CTRL/SD/DMBA−/−, induced control: SD/DMBA+/+, cancerous animals subjected to treatment with NL-C-siRNA: SD/DMBA+/+ NL-C-siRNA, cancerous animals subjected to treatment with NL-mTOR-siRNA: SD/DMBA+/+ NL-mTOR-siRNA. The data are represented as mean ± SEM values and n = 6, ***p < 0.001 and nsp > 0.05. (NL-C-siRNA control siRNA-loaded neutral liposome, NL-mTOR-siRNA mTOR-siRNA-loaded neutral liposome, DMBA 7,12-dimethylbenz[a]anthracene, SD Sprague Dawley, FESEM field emission scanning electron microscope).