Table 2.

Summary of DNA methylation markers in lung cancer early diagnosis

Single/combination marker	Tumor type	Sensitivity(%)	Specificity(%)	Sample type	Reference
P16 RARB2	Lung cancer	69	87	Bronchial aspirates	[36]
RASSF1A	Lung cancer	64	100	Carcinoma tissues	[79]
	Lung cancer	60	90	Brushing sample
RASSF1A	Lung cancer	92	100	Carcinoma tissues	[80]
PCDHGB6 + HOXA9	Lung cancer	80	100	Brushing sample
RASSF1A	NSCLC	87	75	Plasma(cirDNA)	[81]
RARB2	Lung cancer
SHOX2	Squamous cell carcinoma	60	90	Plasma	[82]
SHOX2	Lung cancer	68	95	Alveolar lavage fluid	[83]
SHOX2	Lung cancer	65.5	90	Plasma	[56]
PTGER4	Lung cancer	56.3	90
SHOX2 + PTGER4	Lung cancer	75.6	84.8
SHOX2	Lung cancer	67	90	Plasma	[84]
PTGER4	Lung cancer	90	73
SHOX2 + RASSF1A	Lung cancer	81	97.4	Bronchoalveolar lavage fluid	[85]
HOXA9	NSCLC	55.2	74.3	Plasma	[86]