Table 2.

Separate and mutual associations of serum Hcy and UA with baPWV in males and females

	Unadjusted model			Adjusted model a
	β	95% CI	P value	β	95% CI	P value
Males
Hcy (Per-SD: 7.64 μmol/L)	25.372	20.349, 30.394	< 0.001	7.383	3.979, 10.788	< 0.001
Low Hcy (n = 8896)
High Hcy (n = 3708)	94.471	83.530, 105.412	< 0.001	14.193	6.604, 21.782	< 0.001
UA (Per-SD: 78.65 μmol/L)	− 4.266	− 9.308, 0.776	0.097	7.648	4.113, 11.182	< 0.001
Low UA (n = 9294)
High UA (n = 3310)	4.392	− 7.066, 15.849	0.453	14.740	6.847, 22.633	< 0.001
Low Hcy and low UA (n = 6731)
High Hcy and low UA (n = 2563)	84.652	71.664, 97.641	< 0.001	10.795	1.846, 19.743	0.018
Low Hcy and High UA (n = 2165)	− 13.538	− 27.365, 0.288	0.055	10.958	1.405, 20.510	0.025
High Hcy and high UA (n = 1145)	105.779	87.890, 123.668	< 0.001	30.755	18.355, 43.156	< 0.001
Females
Hcy (Per-SD: 3.98 μmol/L)	63.395	56.112, 70.677	< 0.001	11.003	6.328, 15.679	< 0.001
Low Hcy (n = 3300)
High Hcy (n = 1793)	137.450	122.242, 152.657	< 0.001	21.612	11.711, 31.513	< 0.001
UA (Per-SD: 69.22 μmol/L)	84.683	77.569, 91.797	< 0.001	16.596	11.557, 21.634	< 0.001
Low UA (n = 3588)
High UA (n = 1505)	165.384	149.624, 181.144	< 0.001	38.164	27.514, 48.814	< 0.001
Low Hcy and low UA (n = 2486)
High Hcy and low UA (n = 1102)	110.475	92.321, 128.629	< 0.001	21.628	9.729, 33.527	< 0.001
Low Hcy and High UA (n = 814)	139.512	119.255, 159.769	< 0.001	39.766	26.347, 53.186	< 0.001
High Hcy and high UA (n = 691)	269.763	248.190, 291.335	< 0.001	53.527	38.457, 68.598	< 0.001

Abbreviations: Hcy homocysteine, UA uric acid, baPWV brachial-ankle pulse wave velocity

^aAdjusted for age, education, BMI, physical activity, smoking, drinking, health status, systolic pressure, glucose, triglyceride, HDL-C