Table 3.
Mutual associations of serum Hcy and UA with baPWV in sensitivity analyses
| Males | Females | |||
|---|---|---|---|---|
| β (95% CI) | P value | β (95% CI) | P value | |
| Sensitivity 1 | ||||
| (males: 11,977; females: 4949) | ||||
| Low Hcy and low UA (males: 6423; females: 2447) | ||||
| High Hcy and low UA (males: 2421; females: 1077) | 9.559 (0.486, 18.631) | 0.039 | 22.453 (10.541, 34.364) | < 0.001 |
| Low Hcy and High UA (males: 2077; females: 784) | 9.675 (0.041, 19.310) | 0.049 | 39.588 (26.105, 53.071) | < 0.001 |
| High Hcy and high UA (males: 1056; females: 641) | 31.104 (18.413, 43.795) | < 0.001 | 53.142 (37.869, 68.414) | < 0.001 |
| Sensitivity 2 | ||||
| (males: 10,313; females: 4472) | ||||
| Low Hcy and low UA (males: 5518; females: 2291) | ||||
| High Hcy and low UA (males: 2085; females: 964) | 12.451 (2.654, 22.248) | 0.013 | 22.839 (10.692, 34.987) | < 0.001 |
| Low Hcy and High UA (males: 1793; females: 692) | 9.965 (− 0.407, 20.338) | 0.060 | 37.633 (23.743, 51.523) | < 0.001 |
| High Hcy and high UA (males: 917; females: 525) | 34.165 (20.520, 47.809) | < 0.001 | 55.306 (39.268, 71.344) | < 0.001 |
β is adjusted for age, education, BMI, physical activity, smoking, drinking, health status, systolic pressure, glucose, triglyceride, HDL-C
Sensitivity 1: Excluding participants with cardiovascular diseases; Sensitivity 2: Excluding participants using medications, including anti-hypertensive, anti-diabetic, lipid-lowering, anti-gout, and aspirin
Abbreviations: Hcy homocysteine, UA uric acid, baPWV brachial-ankle pulse wave velocity