Table 4.

Mutual association of serum homocysteine and uric acid with 10-year cardiovascular risk ^a

	Males		Females
	OR (95% CI)	P value	OR (95% CI)	P value
Low Hcy and low UA	Reference		Reference
High Hcy and low UA	1.303 (1.150–1.473)	< 0.001	2.849 (1.683–4.844)	< 0.001
Low Hcy and High UA	1.024 (0.902–1.160)	0.712	3.095 (1.775–5.377)	< 0.001
High Hcy and high UA	1.492 (1.261–1.761)	< 0.001	7.607 (4.629–12.681)	< 0.001

The 10-year risk for men can be calculated as 1 − 0.88936^{exp(ΣβX−23.9802)}, where β is the regression coefficient and X is the level for each risk factor as following equation: ΣβX = 3.06117*log(age) + 1.12370*log(total cholesterol [mg/dL]) − 0.93263*log(HDL cholesterol [mg/dL]) + 0.65451*smoker [yes or no] + 0.57367*diabetes [yes or no] + 1.93303*log(SBP not treated) or 1.99881*log(SBP treated)

The 10-year risk for women can be calculated as 1 − 0.95012^{exp(ΣβX−26.1931)}: ΣβX = 2.32888*log(age) + 1.20904*log(total cholesterol [mg/dL]) − 0.70833*log(HDL cholesterol [mg/dL]) + 0.52873*smoker [yes or no] + 0.69154*diabetes [yes or no] + 2.76157*log(SBP not treated) or 2.82263*log(SBP treated)

Individuals with 10-year cardiovascular risk ≥ 20% are grouped as high risk

Abbreviations: Hcy homocysteine, UA uric acid, SBP systolic blood pressure

^aThe general cardiovascular risk is calculated using the Framingham Heart Study 10-year risk score. The score includes age, sex, total cholesterol, HDL cholesterol, systolic blood pressure, blood pressure lowering medication use, diabetes status, and smoking status in the primary model