| Obese patients with asthma are at high risk of therapy resistance and exacerbations. |
| Obese patients with asthma with or without metabolic syndrome/diabetes may well have different phenotypes of asthma. |
| Current therapy options are insufficient for this phenotype. |
| GLP-1 signaling with significant receptors found in the lungs is an exciting novel target for treatment of chronic airway inflammation in asthma. |
| GLP-1 RAs may improve asthma control and decrease exacerbations with mechanisms including weight loss/mechanical changes as well as anti-inflammatory effect. |
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