Table 2.
Estimated intercept and annualized slope for ppFEV1 using Wang–Hankinson equations (sensitivity analysis)
| Characteristic | F/Fa (n = 11,916) | F/RF (all) (n = 1242) | F/RF (excluding R117H) (n = 889) |
|---|---|---|---|
| Intercept (95% CI) | |||
| Overall | 74.88 (74.49, 75.28) | 86.25 (84.92, 87.58) | 85.49 (83.89, 87.10) |
| 6–12 years of age | 91.88 (91.21, 92.55) | 99.85 (97.34, 102.36) | 100.52 (97.32, 103.71) |
| 13–17 years of age | 81.18 (80.26, 82.10) | 92.02 (88.76, 95.28) | 90.12 (86.32, 93.92) |
| 18–24 years of age | 64.86 (64.02, 65.70) | 80.98 (77.97, 83.99) | 79.78 (76.39, 83.17) |
| ≥ 25 years of age | 56.02 (55.21, 56.83) | 68.34 (66.48, 70.21) | 66.58 (64.40, 68.76) |
| Slope (95% CI) | |||
| Overall | −1.93 (−2.03, −1.82) | −0.74 (−1.14, −0.34) | −1.09 (−1.56, −0.63) |
| 6–12 years of age | −0.75 (−0.90, −0.59) | 0.13 (−0.52, 0.78) | −0.43 (−1.23, 0.36) |
| 13–17 years of age | −3.56 (−3.75, −3.37) | −1.26 (−2.03, −0.49) | −1.43 (−2.30, −0.57) |
| 18–24 years of age | −2.51 (−2.70, −2.33) | −1.39 (−2.17, −0.61) | −1.84 (−2.70, −0.98) |
| ≥ 25 years of age | −1.88 (−2.07, −1.69) | −1.01 (−1.52, −0.49) | −1.11 (−1.71, −0.52) |
F F508del, ppFEV1 percent predicted forced expiratory volume in 1 s, RF residual function
aIntercepts and slopes were calculated by weighting each age group category pooled across the F/F and F/RF (all) cohorts