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. 2022 Dec 6;2:154. doi: 10.1038/s43856-022-00209-1

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© The Author(s) 2022, corrected publication 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Effect of Cloazpine (closed circles) or olanzapine (open circles) on albumin production (a), ALT release (b), and morphology score (c); Effect of troglitazone (closed circles) or pioglitazone (open circles) on albumin production (d), ALT release (e), and morphology score (f); Effect of trovafloxacin (closed circles) or levofloxacin (open circles) on albumin production (g), ALT release (h) and morphology score (i); Immunofluorescence microscopic images showing concentration-dependent increases in caspase 3/7 staining (green;) indicative of apoptosis after treatment with trovafloxacin at 0,1, 10, and 100 (j) times the unbound human C_max for 7 days; concentration-dependent decrease in TMRM staining (yellow) indicative of mitotoxicity in response to treatment with sitaxsentan at 0,1,10, and 100 (k) times the unbound human C_max for 7 days. Scale bar represents 50 µm.