TABLE 3.

PK parameters.

		200 mg BID (n = 10)	300 mg BID (n = 10)	400 mg BID (n = 10)	500 mg BID (n = 10)
Day 1
Tmax, h	Median (range)	1.0 (0.5–1.5)	1.0 (0.5–2.0)	1.2 (0.5–1.5)	1.0 (0.5–1.5)
Cmax, ng/mL	Mean ± SD (%CV)	1890 ± 836 (44.3)	2610 ± 950 (36.4)	3680 ± 1380 (37.5)	4070 ± 1770 (43.4)
	GeoMean (%GeoCV)	1680 (63.1)	2440 (41.8)	3120 (92.9)	3570 (69.1)
AUC0-12h, h*ng/mL	Mean ± SD (%CV)	4610 ± 1530 (33.2)	7520 ± 2910 (38.7)	10500 ± 4300 (41.1)	12800 ± 6120 (47.9)
	GeoMean (%GeoCV)	4270 (50.0)	7100 (35.6)	9280 (67.0)	10900 (75.8)
Day 21
Tmax, h	Median (range)	1.0 (0.5–1.9)	1.0 (0.5–1.5)	1.5 (0.5–2.0)	1.0 (0.5–2.0)
Cmax, ng/mL	Mean ± SD (%CV)	2140 ± 921 (43.1)	3050 ± 1480 (48.6)	4200 ± 1470 (34.9)	4960 ± 1810 (36.5)
	GeoMean (%GeoCV)	1910 (61.3)	2770 (47.7)	3840 (55.0)	4560 (51.5)
AUC0-12h, h*ng/mL	Mean ± SD (%CV)	5510 ± 1800 (32.7)	9780 ± 3750 (38.3)	14700 ± 5010 (34.0)	16800 ± 4900 (29.2)
	GeoMean (%GeoCV)	5180 (42.3)	9180 (38.7)	13600 (50.9)	16000 (36.5)
t1/2, h	Mean ± SD (%CV)	3.2 ± 0.6 (19.3)	3.5 ± 0.6 (16.7)	3.3 ± 0.9 (26.9)	3.3 ± 0.5 (16.2)
	GeoMean (%GeoCV)	3.14 (18.6)	3.48 (17.0)	3.26 (21.8)	3.30 (15.9)
Vz/F, L	Mean ± SD (%CV)	191 ± 93 (48.7)	174 ± 64.6 (37.2)	158 ± 111 (69.9)	156 ± 55.7 (35.8)
	GeoMean (%GeoCV)	175 (44.3)	164 (36.2)	138 (51.6)	149 (30.9)
CL/F, L/h	Mean ± SD (%CV)	42.2 ± 23.1 (54.7)	34.8 ± 13.4 (38.4)	33.7 ± 24.4 (72.3)	33.4 ± 15.1 (45.3)
	GeoMean (%GeoCV)	38.6 (42.3)	32.7 (38.7)	29.4 (50.9)	31.2 (36.5)
Ctrough, ng/mL	Mean ± SD (%CV)	73.3 ± 36.3 (49.6)	171 ± 107 (63.0)	258 ± 128 (49.6)	299 ± 108 (36.0)
	GeoMean (%GeoCV)	66.1 (49.9)	146 (62.1)	229 (58.0)	280 (40.7)
Racc, h	Mean ± SD (%CV)	1.2 ± 0.2 (15.4)	1.3 ± 0.3 (22.2)	1.5 ± 0.4 (24.6)	1.6 ± 0.7 (45.0)
	GeoMean (%GeoCV)	1.21 (15.8)	1.29 (30.1)	1.46 (24.9)	1.46 (43.1)

Data are mean ± SD, unless otherwise specified.