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. 2022 Dec 6;12:21104. doi: 10.1038/s41598-022-25436-3

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Shared and unique genes in 20 C. acnes strains. Venn diagrams display the distribution of shared and unique genes between (a) C. acnes strains from healthy subjects (HS) and the lesional area of acne patients (LA) and (b) phylotypes IA1 and IB/II. Overlapping regions show the genes conserved within strains. The number between brackets represents the unique genes present in all the strains of a particular group. (c) The stacked bar chart of Cluster of Orthologous Genes (COGs) functional category proportions is based on the unique genes in all groups. The n above each group indicates the absolute count of COGs identified in each group. (d) Similarity matrix categories represent the presence (blue; +) or the absence (red, -) of C. acnes virulence genes and phylotype-specific genes.