Table 3.

Cox regression analysis of the factors for cumulative risk of surgical resection in patients with moderate to severe UC exacerbations.

Variables	Univariate analysis		P	Multivariate analysis		P
	Hazard ratio	95% CI		Hazard ratio	95% CI
Age, ≥ 60 years	1.895	1.133–3.170	0.015	2.269	1.341–3.840	0.002
First attack	0.825	0.436–1.560	0.554	0.997	0.511–1.945	0.993
Pancolitis UC	1.432	0.924–2.221	0.108	1.156	0.737–1.813	0.528
Severe exacerbation	3.954	2.545–6.142	< 0.001	2.973	1.860–4.754	< 0.001
History of COR-REF or DEP	3.986	2.576–6.167	< 0.001	2.920	1.806–4.720	< 0.001
Corticosteroids	0.569	0.368–0.879	0.011	0.666	0.419–1.057	0.085
Apheresis	2.021	1.302–3.136	0.002	1.807	1.132–2.884	0.013
Calcineurin inhibitors	5.059	3.246–7.884	< 0.001	2.695	1.657–4.383	< 0.001
Biologics	1.355	0.849–2.164	0.203	0.913	0.556–1.499	0.719