Table 4.

Cox regression analysis of the factors for cumulative risk of re-exacerbation in patients with moderate to severe UC exacerbations.

Variables	Univariate analysis		P	Multivariate analysis		P
	Hazard ratio	95% CI		Hazard ratio	95% CI
Age, ≥ 60 years	0.828	0.611–1.115	0.214	0.813	0.603–1.096	0.174
First attack	0.976	0.771–1.236	0.839	0.803	0.612–1.054	0.113
Pancolitis UC	1.227	1.015–1.484	0.035	1.217	1.065–1.391	0.004
Severe exacerbation	1.238	1.000–1.533	0.050	1.133	0.902–1.424	0.283
History of COR-REF or DEP	0.846	0.664–1.077	0.173	0.930	0.716–1.209	0.589
5-ASA	1.046	0.859–1.274	0.652	1.161	0.911–1.480	0.226
Corticosteroids	1.436	1.164–1.772	0.001	1.473	1.183–1.833	0.001
Apheresis	0.992	0.803–1.226	0.944	0.977	0.785–1.216	0.837
Calcineurin inhibitors	1.115	0.886–1.404	0.353	1.206	0.939–1.549	0.142
Immunomodulators	1.051	0.754–1.467	0.768	1.066	0.760–1.480	0.712
Biologics	0.527	0.389–0.713	< 0.001	0.501	0.367–0.683	< 0.001