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. 2022 Dec 6;12:21057. doi: 10.1038/s41598-022-25520-8

Table 1.

Demographic characteristics of the study population.

No AECOPD AECOPD P-value
Sample size 306 138
Monocyte% 8.6(6.7,10.4) 8.7(6.5,11.2) 0.605
 Low at < 7.5% 95(31.05%) 51(36.96%) 0.003
 Medium at 7.5 to < 10% 117(38.24%) 30(21.74%)
 High at ≥ 10% 94(30.72%) 57(41.3%)
Monocyte count 60.62(44.16,79.92) 67.08(51.12,94.01) 0.004
FEV1_post 1.43(1.06,1.85) 1.23(0.87,1.63) 0.001
FEV1_post% 61.95(47.9,75.5) 53.9(39.5,66.8)  < 0.001
FEV1/FVC_post% 61.13(52.66,67.12) 59.53(50.28,65.27) 0.035
CAT 3(2,5) 5(4,8)  < 0.001
  ≤ 10 303(99.02%) 128(92.75%)  < 0.001
  > 10 3(0.98%) 10(7.25%)
MMRC 2(1,2) 2(1,2) 0.110
 0 36(11.76%) 5(3.62%) 0.055
 1 100(32.68%) 48(34.78%)
 2 144(47.06%) 73(52.9%)
  ≥ 3 26(8.5%) 12(8.7%)
Gender, Male 270(88.24%) 124(89.86%) 0.617
Age 72(65,81) 74(67,81) 0.383
Cough 150(49.02%) 100(72.46%)  < 0.001
Dyspnea 116(37.91%) 78(56.52%)  < 0.001
Wheeze 95(31.05%) 84(60.87%)  < 0.001
Chest tight 43(14.05%) 21(15.22%) 0.746
Chest pain 24(7.84%) 14(10.14%) 0.422
HPT 144(47.06%) 82(59.42%) 0.047
DM 68(22.22%) 39(28.26%) 0.317
Hyperlipidemia 74(24.18%) 33(23.91%) 0.795
CHF 15(4.9%) 17(12.32%) 0.016
CPD 157(51.31%) 96(69.57%)  < 0.001
Heart failure 50(16.34%) 27(19.57%) 0.572
Sleep disorder 99(32.35%) 61(44.2%) 0.016
malignancy 44(14.38%) 30(21.74%) 0.128
Pneumonia 34(11.11%) 37(26.81%)  < 0.001
Eosinophil 1.7(0.8,3.4) 1.45(0.5,3.5) 0.495
Lymphocyte 21.3(13.4,30) 19.8(11,28.5) 0.106
Neutrophil 65(56.3,76.1) 67.3(55.8,79.3) 0.353
Eosinophil to Lymphocyte 0.08(0.04,0.15) 0.08(0.03,0.18) 0.927
  < 0.049 110(35.95%) 40(28.99%) 0.357
 0.049 to < 0.122 98(32.03%) 49(35.51%)
  >  = 0.122 98(32.03%) 49(35.51%)
Neutrophil to Lymphocyte 3(1.88,5.63) 3.34(1.98,7.21) 0.146
Platelet count 205.5(162,246) 195.5(161,237) 0.368
WBC count 7(5.6,9.1) 7.95(6.4,10.3)  < 0.001
RBC count 4.51(4.09,4.86) 4.55(4.22,4.86) 0.260
Hb 13.75(12.2,15) 13.9(12.8,15) 0.358
RDW 13.85(13.3,14.5) 13.9(13.4,14.7) 0.540
pH 6.68(6,7.32) 7(6,7.38) 0.428
Basophil 0.5(0.4,0.8) 0.6(0.4,0.8) 0.849
MPV 8(7.4,8.6) 8.1(7.5,8.9) 0.306
CRP 0.77(0.13,3.85) 0.62(0.14,4.21) 0.828
COPD medication within 6 months
 Mono- therapy 46(15.03%) 25(18.12%) 0.412
 Dual- therapy 191(62.42%) 95(68.84%) 0.191
 Triple- therapy 51(16.67%) 46(33.33%)  < 0.001
Oral long-acting bronchodilators 14(4.58%) 21(15.22%)  < 0.001
Methylxanthines 182(59.48%) 108(78.26%)  < 0.001
SBP 133.8(125,145.4) 133(124,145) 0.973
DBP 75(68,81) 76(70,82) 0.289
Pulse rate 83(75,92) 84(74,95) 0.650
Breathing 18(18,20) 18(18,19) 1.000
BMI 23.82(21.21,26.17) 23.38(21.19,26.01) 0.490
Smoking status
 Never smoker 66(21.57%) 27(19.57%) 0.605
 Former smoker 194(63.4%) 94(68.12%)
 Current smoker 46(15.03%) 17(12.32%)