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. 2022 Nov 23;13:1052644. doi: 10.3389/fphar.2022.1052644

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Copyright © 2022 You, Xiao, Lu, Du, Cai, Cai and Yan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MDP alleviates DSS-induced intestinal injury in C57BL/6 mice. (A) Experimental timeline was shown. C57BL/6 mice were divided into four groups: PBS group, MDP group, DSS + PBS group, and DSS + MDP group (n = 6, each group). Each group received continuous intraperitoneal injections (i.p.) of MDP (100 μg) or sterile PBS 100 μL from Day 1 to Day 3, respectively. The mice drank water or 3% DSS from Day 1 to Day 7. (B) Body weight of mice was recorded every day. (C) Weight loss, stool consistency, and blood of mice were observed for evaluating disease activity index scores. (D,E) Mice were euthanized on Day 8. The colon was taken and the length was measured and photographed. Data were expressed as mean ± SEM. *p <0.05, ***p <0.001, ****p <0.0001, ns, not significant, One-way or Two-way ANOVA.