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. 2022 Dec 6;12:21109. doi: 10.1038/s41598-022-25540-4

Table 3.

Hazard ratios (HRs) and 95% confidence intervals (CIs) for distant metastasis-free survival (DMFS).

Univariate analysis Multivariate analysis
HRs (95% CIs) p value HRs (95% CIs) p value
Age (continuous) 1.024 (0.968–1.082) 0.408 N/A
BMI 1.005 (0.861–1.173) 0.949 N/A
ER 0.119 N/A
 Negative 1
 Positive 0.569 (0.200–1.624)
PR 0.098 N/A
 Negative 1
 Positive 0.397 (0.133–1.184)
HER2 0.836 N/A
 Negative 1
 Positive 1.131 (0.355–3.605)
HG 0.994 N/A
 I, II 1
 III 0.998 (0.562–1.772)
Tumor size 0.119 N/A
 ≤ 2 cm 1
  > 2 cm 2.320 (0.804–6.688)
Lymph node metastasis 0.052 N/A
 Negative 1
 Positive 2.859 (0.992–8.241)
AJCC stage 0.015 0.019
 I 1 1
 II 6.024 (1.301–27.886) 5.810 (1.255–26.900)
 III 7.125 (1.190–42.650) 6.631 (1.106–39.734)
Lymphovascular invasion 0.693 N/A
 Negative 1
 Positive 1.301 (0.352–4.815)
SUVmean-VAT 0.031 0.039
 Low 1 1
 High 4.066 (1.134–14.580) 3.846 (1.072–13.795)
Chemotherapy 0.392 N/A
 Not done 1
 Done 0.630 (0.218–1.815)
Radiotherapy 0.915 N/A
 Not done 1
 Done 0.944 (0.327–2.723)
Endocrine therapy 0.082 N/A
 Not done 1
 Done 0.390 (0.135–1.125)

BMI Body mass index; ER Estrogen receptor; PR Progesterone receptor; HER2 Human epidermal growth factor receptor 2; HG Histologic grade; VAT Visceral adipose tissue; N/A Not assessed.