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The role of plasmid and genomic island-encoded factors in the spread of AMR encoding genes. The mobility of selective Inc conjugative plasmid carrying the ARGs depends mostly on the master activator AcaCD regulon. The AcaCD supported expression of xis and mobIM helps in the excision and mobilization of AMR encoding genes, respectively. The fitness costs in bacteria has been minimized through plasmid/chromosomal compensatory mutations.
