. 2022 Nov 23;13:1055765. doi: 10.3389/fphar.2022.1055765

TABLE 3.

Effect of the oral administration of dihydro p-coumaric acid haematological parameters in acute toxicity studies.

Parameters	Unit	Normal group	200 mg/kg BW	800 mg/kg BW	1,600 mg/kg BW
White bool cell (WBC)	10⁹/l	6.55 ± 0.19^c	5.77 ± 0.32^b	6.65 ± 0.30^c	3.92 ± 0.53^a
Lymphocyte (LYM)	%	81.47 ± 1.15^b	80.12 ± 1.6^b	80.1 ± 0.46^b	78.27 ± 1.20^a
Monocyte (MONO)	%	5.6 ± 0.56^a	6.1 ± 0.41^b	5.17 ± 0.20^a	6.52 ± 0.49^c
Granulocyte (GRAN)	10⁹/l	0.83 ± 0.1^c	0.75 ± 0.04^b	0.95 ± 0.06^d	0.55 ± 0.06^a
Granulocyte (GRAN)	%	12.9 ± 1.15^a	13.7 ± 1.18^a	14.72 ± 0.41^b	15.2 ± 0.71^b
Haemoglobin (HGB)	g/dl	17.3 ± 0.19^a	16.7 ± 0.81^a	17.55 ± 0.18⁰	17.42 ± 0.23^a
Haematocrit (HCT)	%	44.85 ± 0.03^a	44.75 ± 0.12^a	46.85 ± 0.29^a	46.55 ± 0.25^a
Red blood cell (RBC)	10¹²/l	9.26 ± 0.06^b	9.20 ± 0.40^b	7.34 ± 1.45^a	9.43 ± 0.09^b
Mean corpuscular volume (MCV)	fl	48.38 ± 0.35^b	48.55 ± 0.22^b	47.5 ± 0.59^a	49.37 ± 0.42^c
Mean corpuscular haemoglobin (MCH)	Pg	18.68 ± 0.13^c	18.12 ± 0.10^b	17.7 ± 0.08^a	18.5 ± 0.16^c
Mean corpuscular haemoglobin concentration (MCHC)	g/dl	38.63 ± 0.39^b	37.35 ± 0.10^a	37.47 ± 0.33^a	37.42 ± 0.34^a
Red cell distribution width (RDW)	%	17.73 ± 0.32^b	17.07 ± 0.10^a	17.02 ± 0.33^a	17.37 ± 0.30^b
Mean platelet volume (MPV)	fl	4.73 ± 0.22^a	4.8 ± 0.19^a	5.25 ± 0.14^b	4.9 ± 0.04^a

Values are expressed as mean ± SEM (df = 3) followed by the same letter of the alphabet (a, b, c) do not differ significantly each other (ANOVA, Tukey test post-hoc, p > 0.05).