. 2022 Nov 23;13:1055765. doi: 10.3389/fphar.2022.1055765

TABLE 4.

Effect of the oral administration of dihydro-p-coumaric acid on haematological parameters in the sub-acute toxicity studies.

Parameters	Unit	Normal group	50 mg/kg bw enriched fraction	500 mg/kg bw enriched fraction
Male
White bool cell (WBC)	10⁹/l	6.86 ± 1.01^b	4.97 ± 0.42^a	7.04 ± 0.43^b
Lymphocyte (LYM)	%	79.36 ± 0.90^a	81.1 ± 1.57^b	81.28 ± 1.59^b
Monocyte (MONO)	%	4.12 ± 0.34^a	4.52 ± 0.27^a	4.28 ± 0.26^a
Granulocyte (GRAN)	10⁹/l	1.06 ± 0.13^b	0.7 ± 0.10^a	1.02 ± 0.08^b
Granulocyte (GRAN)	%	16.52 ± 1.14^b	14.37 ± 1.37^a	14.7 ± 1.39^a
Haemoglobin (HGB)	g/dl	16.24 ± 1.56^a	18.17 ± 1.20^b	19.86 ± 0.79^c
Haematocrit (HCT)	%	44.18 ± 3.87^a	49.67 ± 3.72^b	52.16 ± 1.67^c
Red blood cell (RBC)	10¹²/l	8.94 ± 0.84^a	10.37 ± 0.77^b	10.73 ± 0.32^b
Mean corpuscular volume (MCV)	Fl	49.5 ± 0.43^b	47.85 ± 0.35^a	47.9 ± 0.12^a
Mean corpuscular haemoglobin (MCH)	Pg	18.12 ± 0.15^b	17.67 ± 0.68^a	18.28 ± 0.16^b
Mean corpuscular haemoglobin concentration (MCHC)	g/dl	36.66 ± 0.48^a	36.9 ± 1.34^a	38.28 ± 0.34^b
Red cell distribution width (RDW)	%	18.26 ± 0.93^b	17.55 ± 0.24^a	18.44 ± 0.28^b
Mean platelet volume (MPV)	Fl	4.54 ± 0.18^a	5.2 ± 0.22^b	4.64 ± 0.17^a
Female
White bool cell (WBC)	10⁹/l	5.8 ± 0.59^b	4.52 ± 0.43^a	5.76 ± 0.30^b
Lymphocyte (LYM)	%	80.72 ± 1.67^b	77.1 ± 1.30^a	78.8 ± 0.86^a
Monocyte (MONO)	%	5.18 ± 0.12^c	4.94 ± 0.22^b	4.66 ± 0.12^a
Granulocyte (GRAN)	10⁹/l	0.78 ± 0.04^a	0.78 ± 0.10^a	0.9 ± 0.05^b
Granulocyte (GRAN)	%	14.1 ± 1.30^a	17.96 ± 1.15^c	16.48 ± 0.95^b
Haemoglobin (HGB)	g/dl	17.52 ± 0.70^a	18.24 ± 0.64^b	20.32 ± 0.55^c
Haematocrit (HCT)	%	44.84 ± 2.10^a	46.36 ± 1.94^b	52.56 ± 1.43^c
Red blood cell (RBC)	10¹²/l	9.24 ± 0.41^a	9.7 ± 0.36^a	10.79 ± 0.27^b
Mean corpuscular volume (MCV)	fl	48.44 ± 0.12^b	47.76 ± 0.24^a	48.66 ± 0.11^b
Mean corpuscular haemoglobin (MCH)	Pg	18.9 ± 0.18^a	18.82 ± 0.04^a	18.8 ± 0.1^a
Mean corpuscular haemoglobin concentration (MCHC)	g/dl	39.16 ± 0.4^b	39.42 ± 0.29^b	38.62 ± 0.15^a
Red cell distribution width (RDW)	%	17.78 ± 0.25^a	20.12 ± 0.29^c	19.3 ± 0.17^b
Mean platelet volume (MPV)	fl	5.24 ± 0.08^b	5.04 ± 0.09^a	5.1 ± 0.05^a

Values are expressed as mean ± SEM (df = 4) followed by the same letter of the alphabet (a, b, c) do not differ significantly each other (ANOVA, Tukey test post-hoc, p > 0.05).