TABLE 1.

The PK parameters of six ingredients in rat plasma after i.v., administration of SI with low and high dosages (Mean ± SD).

Analyte	Group	t 1/2	Cmax	AUC0-t	AUC0-∞	Vd	Cl	MRT0-t	MRT0-∞
		(h)	(ng/ml)	(h·ng/ml)	(h·ng/ml)	(L/kg)	[L/(h·kg)]	(h)	(h)
SYR	Low	0.25 ± 0.09	259.50 ± 59.35	100.67 ± 57.37	115.88 ± 70.51	0.21 ± 0.07	0.69 ± 0.43	0.27 ± 0.10	0.38 ± 0.16
	Medium	0.61 ± 0.25	465.33 ± 42.92	363.24 ± 81.55	367.67 ± 78.73	0.31 ± 0.20	0.34 ± 0.07	0.69 ± 0.07	0.75 ± 0.14
	High	0.53 ± 0.23	925.33 ± 38.55	585.69 ± 94.42	591.71 ± 96.56	0.31 ± 0.11	0.41 ± 0.07	0.67 ± 0.21	0.71 ± 0.23
HSYA	Low	0.47 ± 0.07	2,624.50 ± 660.17	2,479.11 ± 1,312.76	2,490.30 ± 1,317.76	0.09 ± 0.04	0.13 ± 0.07	0.76 ± 0.19	0.78 ± 0.19
	Medium	0.64 ± 0.08	5,628.33 ± 405.14	5,074.18 ± 328.93	5,461.77 ± 202.42	0.09 ± 0.01	0.10 ± 0.00	0.79 ± 0.14	0.97 ± 0.06
	High	0.46 ± 0.12	14,077.33 ± 17.21	11,015.37 ± 1,025.71	11,453.34 ± 668.38	0.06 ± 0.02	0.09 ± 0.01	0.70 ± 0.09	0.78 ± 0.11
p-CA	Low	0.08 ± 0.05	305.00 ± 147.31	62.45 ± 50.04	67.71 ± 57.20	0.11 ± 0.03	1.21 ± 0.76	0.10 ± 0.05	0.12 ± 0.07
	Medium	0.22 ± 0.06	715.00 ± 85.75	265.09 ± 89.73	277.26 ± 84.05	0.13 ± 0.07	0.40 ± 0.13	0.27 ± 0.03	0.33 ± 0.01
	High	0.21 ± 0.05	1,255.00 ± 69.07	432.92 ± 44.53	469.10 ± 38.10	0.14 ± 0.03	0.45 ± 0.04	0.25 ± 0.04	0.32 ± 0.04
SCU	Low	—	—	—	—	—	—	—	—
	Medium	2.58 ± 1.84	162.20 ± 17.41	89.76 ± 21.01	104.73 ± 31.46	0.05 ± 0.02	0.01 ± 0.01	1.46 ± 0.64	2.90 ± 2.42
	High	2.84 ± 1.19	327.33 ± 60.05	305.74 ± 12.47	358.05 ± 33.97	0.03 ± 0.01	0.01 ± 0.00	1.57 ± 0.68	2.96 ± 1.49
p-HBA	Low	—	—	—	—	—	—	—	—
	Medium	0.48 ± 0.11	44.67 ± 5.13	20.15 ± 4.40	23.41 ± 5.21	0.35 ± 0.04	0.53 ± 0.11	0.43 ± 0.04	0.67 ± 0.11
	High	0.39 ± 0.35	74.33 ± 2.52	35.19 ± 31.15	44.04 ± 45.17	0.34 ± 0.09	0.99 ± 0.66	0.32 ± 0.25	0.53 ± 0.53
RU	Low	—	—	—	—	—	—	—	—
	Medium	—	—	—	—	—	—	—	—
	High	0.24 ± 0.04	39.33 ± 1.53	12.38 ± 1.37	15.10 ± 2.23	0.30 ± 0.02	0.86 ± 0.13	0.22 ± 0.03	0.36 ± 0.06
Con.sum	Low	0.47 ± 0.07	3,167.75 ± 816.03	2,652.33 ± 1,429.09	2,663.49 ± 1,433.99	0.12 ± 0.06	0.18 ± 0.10	0.73 ± 0.18	0.75 ± 0.18
	Medium	0.67 ± 0.03	7,028.20 ± 327.77	6,118.67 ± 358.43	6,121.59 ± 360.32	0.12 ± 0.01	0.13 ± 0.01	0.92 ± 0.06	0.93 ± 0.06
	High	0.61 ± 0.19	16,654.00 ± 83.47	12,888.28 ± 601.42	12,905.39 ± 600.72	0.10 ± 0.04	0.12 ± 0.01	0.76 ± 0.05	0.77 ± 0.05
AUC integrated	Low	0.47 ± 0.07	2,479.02 ± 623.45	2,331.72 ± 1,235.38	2,342.22 ± 1,240.07	0.09 ± 0.04	0.13 ± 0.07	0.76 ± 0.19	0.78 ± 0.19
	Medium	0.64 ± 0.08	4,977.67 ± 350.18	4,314.31 ± 162.32	4,651.87 ± 328.87	0.09 ± 0.01	0.10 ± 0.01	0.79 ± 0.15	0.98 ± 0.05
	High	0.45 ± 0.13	12,613.33 ± 15.31	9,842.06 ± 914.28	10,231.64 ± 594.87	0.06 ± 0.02	0.09 ± 0.01	0.69 ± 0.09	0.78 ± 0.11
Effect weighting integrated	Low	0.47 ± 0.07	2,565.28 ± 644.69	2,419.83 ± 1,281.52	2,430.74 ± 1,286.40	0.09 ± 0.04	0.13 ± 0.07	0.76 ± 0.19	0.78 ± 0.19
	Medium	0.80 ± 0.18	5,498.98 ± 395.38	5,178.98 ± 544.93	5,337.30 ± 637.82	0.11 ± 0.02	0.10 ± 0.01	0.91 ± 0.11	1.03 ± 0.13
	High	0.58 ± 0.20	13,737.03 ± 17.63	11,273.38 ± 1,221.77	11,861.16 ± 262.38	0.07 ± 0.02	0.09 ± 0.00	0.70 ± 0.09	0.83 ± 0.17

Low dose group, n = 4; medium and high groups, n = 3, respectively. The plasma drug concentration was low, so the PK, parameters could not be calculated.