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Kinetic parameters of the β-lactamase LAQ-1 for β-lactam antimicrobials.
| Substrate | Km (μM) | kcat (s−1) | kcat/Km (μM−1·s−1) |
|---|---|---|---|
| Piperacillin | 87.56 | 9,428.44 | 107.68 |
| Ampicillin | 436.1 | 9,141.15 | 20.96 |
| Cefepime | 57.05 | 466.64 | 8.18 |
| Cefoxitin | 65.4 | 1,106.67 | 16.92 |
| Cefazolin | 645 | 25,725.41 | 39.88 |
| Ceftazidime | 140 | 641.61 | 4.58 |
| Aztreonam | NHa | NHa | NHa |
| Meropenem | NHa | NHa | NHa |
| Imipenem | NHa | NHa | NHa |
Values are the means of three independent measurements. aNH, no detectable hydrolysis.
