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. 2022 Nov 23;13:1060104. doi: 10.3389/fphar.2022.1060104

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Copyright © 2022 Li, Yang, Li, Wang, Liu, Chen and Diao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cor inhibited NLRP3 inflammasome activation and alleviated pyroptosis in OGD/R injured MLE-12 cells. (A) Cytotoxicity of Cor on MLE-12 cells. (B) The protective effects of Cor on the OGD/R injured MLE-12 cells. (C) The effects of Cor on OGD/R injured MLE-12 cell with pre-treatment for different times. (D) Pyroptosis determination of MLE-12 cells using Hoechst 33342/PI double staining (scale bars = 50 μm). (E) The ROS determination of MLE-12 cells (scale bars = 100 μm). (F) The protein expression levels of NLRP3, ASC, caspase 1 P20, and GSDMD-NT in MLE-12 cells. Data are expressed as the mean ± SEM (n ≥ 3), ^# p < 0.05 and ^## p < 0.01 vs. sham group, *p < 0.05 and **p < 0.01 vs. OGD/R group.