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. 2022 Nov 23;13:1060104. doi: 10.3389/fphar.2022.1060104

FIGURE 5.

FIGURE 5

Cor inhibited the NLRP3 inflammasome pathway activated by LPS and Nigericin in RAW264.7/MLE-12 cells. (A) The effects of Cor on cell viability of LPS and nigericin treated RAW264.7 and MLE-12 cells. (B) The effects of Cor on LDH levels in LPS and nigericin treated RAW264.7 and MLE-12 cells. (C) The effects of Cor on the protein expression levels of NLRP3 and GSDMD-NT in LPS and nigericin treated RAW264.7 and MLE-12 cells. (D,E) The effects of Cor on the percentages of cells with ASC specks in LPS and nigericin treated RAW264.7 and MLE-12 cells. Data are expressed as the mean ± SEM (n≥3), # p < 0.05 and ## p < 0.01 vs. sham group, *p < 0.05 and **p < 0.01 vs. LPS and nigericin treated group.