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. 2022 Nov 23;13:1043945. doi: 10.3389/fphar.2022.1043945

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Copyright © 2022 Li, Jiang, Dai, Yu, Lv, Zhang, Liao, Ao, Hu, Meng, Peng, Tao and Xie.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mefunidone reduced IRI-induced oxidative stress accumulation. (A) DHE immunofluorescence staining for ROS detection in the renal tissues on day 2 after IRI modeling (×200). (B) Renal MDA level in the renal tissues on day 2 after IRI modeling. (C) RT-qPCR of CAT in the renal tissues on day 2 after IRI modeling. (D) RT-qPCR of mnSOD in the renal tissues on day 2 after IRI modeling. Mefunidone: 100 mg/kg. Data represent mean ± SEM (n = 3–5). *p < 0.05, vs. Sham group; **p < 0.01, vs. Sham group; ***p < 0.001, vs. Sham group; ^# p < 0.05, vs. IRI group; ^## p < 0.01, vs. IRI group.