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. 2022 Nov 23;13:1043945. doi: 10.3389/fphar.2022.1043945

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Copyright © 2022 Li, Jiang, Dai, Yu, Lv, Zhang, Liao, Ao, Hu, Meng, Peng, Tao and Xie.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mefunidone protected IRI-induced mitochondrial damage and complex Ⅲ and Ⅴ of mitochondrial electron transport chain complex (A) Electron microscope analysis of mitochondria in the renal tissues on day 2 after IRI modeling (×8,000). (B,C) Western blot analysis and quantitative data of bax and bcl2 in the renal tissues on day 2 after IRI modeling. (D,E) Western blot analysis and quantitative data of mitochondrial electron transport chain complex in the renal tissues on day 2 after IRI modeling. Mefunidone: 100 mg/kg. Data represent mean ± SEM (n = 3). *p < 0.05, vs. Sham group; **p < 0.01, vs. Sham group; ^# p < 0.05, vs. IRI group.