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. 2022 Nov 23;9:1020006. doi: 10.3389/fcvm.2022.1020006

FIGURE 2.

FIGURE 2

Sex-specific differences in cardiometabolic fitness of MetS KKAy+/–ApoE–/– and non-MetS KKAy–/–ApoE–/– mice using Treadmill Exercise Test. Mice were trained on the treadmill on day 1 and tested using a treadmill exercise test on day 2 with gradial increase in speed at constant incline. Shown are (A) maximum oxygen consumption (VO2max), (B) carbon dioxide produced relevant to maximal oxygen uptake (VCO2max), (C) maximum running speed, (D) maximum runtime until exhaustion. Line graphs depicting average RER for (E) representative male MetS KKAy+/–ApoE–/– (YM) and non-MetS KKAy–/–ApoE–/– (BM) mice and (F) representative female MetS KKAy+/–ApoE–/– (YF) and non-MetS KKAy–/–ApoE–/– (BF) mice. For panels (A–D), data are mean ± SEM. For all the panels n = 5–7 mice per genotype. *p < 0.05, **p < 0.005.