TABLE 1.

Study on IL-6 in SARS-CoV-2, SARS-CoV and MERS-CoV.

Abbreviations	Terms
ACE2	angiotensin converting enzyme 2
ALI	acute lung injury
AP-1	activator protein 1
ARDS1	acute respiratory distress syndrome 1
CAR-T	chimeric antigen receptor-T
CEST	Central European summer Time
COVID-19	Corona Virus Disease 2019
CRP	C-reactive protein
CRS	cytokine release syndrome
DAMPs	Damage-associated molecular patterns
Gab1	GRB2 associated binding protein 1
GRB2	growth factor receptor-bound protein 2
GvHD	graft-versus-host disease
HCOVs	human coronaviruses
HCWs	health care workers
HMGB1	high mobility group box 1
IL	interleukin
IPC	infection prevention and control
IRF-1	interferon regulatory factor 1
JAK	Janus kinase
LPS	Lipopolysaccharide
LRT	lower respiratory tract
MAPK	mitogen-activated protein kinase
MAS	macrophage activation syndrome
MERS	Middle East respiratory sickness
MERS-CoV	Middle East Respiratory Syndrome Coronavirus
mIL-6R	membrane-bound IL6R
MMP-9	matrix metalloproteinase-9
NF-IL-6	nuclear factor IL-6
NF-κB	nuclear factor kappa-B
PAMPs	pathogen-associated molecular patterns
PBMC	peripheral blood mononuclear cell
PCT	procalcitonin
PI3K	phosphatidylinositol 3-kinase
PRRs	Pathogen-recognition receptors
RA	rheumatoid arthritis
RAGE	receptor for advanced glycation end products
SAA	serum amyloid A
SARS	severe acute respiratory syndrome
SARS-CoV	Severe Acute Respiratory Syndrome Coronavirus
SARS-CoV-2	Severe Acute Respiratory Syndrome Coronavirus 2
SHP-2	Src homology phosphotyrosine phosphatase 2
sIL-6R	soluble IL-6R
SP1	specificity protein 1
TG	thioglycollate
Th17	T helper 17
TLRs	toll-like receptors
TMPRSS2	transmembrane protease serine 2
TNF-α	tumor necrosis factor-α
WHO	World Health Organization