TABLE 1.
The list of circRNAs in OC.
| Gene name | Regulation | Tissue | Cell lines | Functions | Mechanism | Target genes | Source |
|---|---|---|---|---|---|---|---|
| circHIPK3 | ↑ | n = 21; n = 69 | A2780, SKOV3, IOSE80; A2780, HO8910, SKOV3, CAOV3, HOEC | facilitated the proliferation, migration and invasion of ovarian cancer cells and suppressed apoptosis; correlated with lymph node infiltration, FIGO stage, patients’ DFS and OS | miRNA sponge; a novel biomarker for EOC prognosis | miR-10a-5p is the most abundant miRNA related | (Liu et al., 2018; Teng et al., 2019) |
| circEXOC6B | ↓ | n = 54 | potential diagnostic biomarkers | Ning et al. (2018) | |||
| circ N4BP2L2 | ↓ | n = 54 | potential diagnostic biomarkers | Ning et al. (2018) | |||
| circRNA1656 | ↓ | n = 3 | SKOV3, HO8910, A2780, OVCAR-3, human ovarian epithelial cells | significantly associated with HGSOC FIGO stage | a novel tumor marker | Gao et al. (2019) | |
| hsa_circ_0003972 | ↓ | n = 41/15 | A2780, SKOV3, IOSE386 | possessed diagnostic value, may function as ceRNA | new circulating biomarkers | Ge et al. (2022) | |
| hsa_circ_0007288 (circCOMBO) | ↓ | n = 41/15 | A2780, SKOV3, IOSE386 | possessed diagnostic value, may function as ceRNA | new circulating biomarkers | Ge et al. (2022) | |
| circ_0078607 | ↓ | n = 18 | SKOV3, A2780 | inhibits the proliferation and invasion of OC cells and promoting apoptosis | sponge miR-518a-5p inducing Fas expression | miR-518a-5p | Zhang et al. (2020c) |
| circLARP4 | ↓ | n = 78 | correlated significantly with FIGO staging and lymph node metastases | a potential biomarker of OC prognosis | Zou et al. (2018) | ||
| VPS13C-hsa-circ-001567 | ↑ | n = 20 | IOSE80, ES-2, SKOV3, Caov-3, and OV-1063 | VPS13C-has-circ-001567 plays a role in the development of OC | a prognostic marker and therapeutic target | Bao et al. (2019) | |
| circFoxp1 | ↑ | n = 194 | COC1, OVCAR3, SKOV3, SKOV3/DDP, IOSE-80 | circFoxp1 can serve as a biomarker for EOC and a potential therapeutic target | circulating exosome | Luo and Gui, (2020) | |
| circ-LPAR3 | ↑ | SKOV3, A2780 | enhances theDDP resistance of OC | miR-634/PDK1 axis | miR-634 | Liu et al. (2022a) | |
| circITGB6 | ↑ | n = 119 | OVCAR3, SKOV3, TOV21G, TOV112D, CAOV3, A2780 | promotes M2 macrophage-dependent CDDP resistance | circITGB6/IGF2BP2/FGF9 RNA-protein ternary complexes | IGF2BP2 and FGF9 mRNA | Li et al. (2022) |
| circPLEKHM3 | ↓ | n = 35 | SKOV3, A2780, 293 T | curcumin restrained proliferation and facilitated apoptosis | circPLEKHM3/miR-320a/SMG1 axis | miR-320a | Sun and Fang, (2021) |
| circFoxp1 | ↑ | n = 194 | COC1, OVCAR3, SKOV3, SKOV3/DDP, IOSE-80 | induces DDP resistance in EOC cells and positively regulates the expression of CEBPG and FMNL3 | miR-22 and miR-150-3p | miR-22 and miR-150-3p | Luo and Gui, (2020) |
| circVPS13C | ↑ | n = 40 | IOSE-80, A2780, SKOV3, 293 T | propofol inhibits OC cell proliferation, cell cycle, migration and invasion and induces apoptosis | circVPS13C/miR-145/MEK/ERK | miR-145 | Lu et al. (2021) |
| circ-ZFR | A2780 | propanol inhibits glycolysis and cancer cell progression | circ-ZFR/miR-212-5p/SOD2 axis | miR-212-5p | Qu et al. (2022) | ||
| circRNA-UBAP2 | ↑ | n = 20 | IOSE80, SKOV3, OVCAR-3, ES-2, A2780 | promote OC cell proliferation and inhibit apoptosis | circRNA-UBAP2/miR-382-5p/PRPF8 axis | miR-382-5p | Xu et al. (2020) |
| circMTO1 | ↓ | n = 48 | SKOV3, OVCAR3, IOSE80 | inhibition of OC progression | miR-182-5p/KLF15 axis | miR-182-5p | Wang et al. (2020) |
| circE2F2 | ↑ | n = 70 | OVCAR-3, SKOV3, A2780, CAOV3, IGROV1, ES2, HOSEpiC | promotes OC cell proliferation, metastasis and glucose metabolism | stabilizes E2F2 mRNA by binding to HuR protein | E2F2 mRNA | Zhang et al. (2021a) |
| circular RNA-ITCH | ↓ | n = 75 | UWB1.289 + BRCA1, UWB1.289 | suppress the proliferation of OC | down-regulating HULC | Yan et al. (2020) | |
| Circ-ITCH | ↓ | SKOV3, A-2780, OVCAR-3, HO-8910, IOSE80 | inhibits EOC cell proliferation and promotes apoptosis | sponging of miR-10a | miR-10a | Luo et al. (2018) | |
| Circ-ITCH | ↓ | n = 20 | SK-OV-3, Caov-3 | inhibits the malignant progression of OC | circ-ITCH-miR-145-RASA1 axis | miR-145 | Hu et al. (2018) |
| hsa_circ_0051240 | ↑ | n = 33 | CAOV-3, SKOV-3, OVCAR-3, H8910, HOSE | promotes OC proliferation, migration and invasion | hsa_circ_0051240/miR-637/KLK4 axis | miR-637 | Zhang et al. (2019b) |
| Circ-PVT1 | ↑ | CAOV3, SKOV3, OVCAR3, HOSEpiC | promotes EOC cell proliferation but inhibits apoptosis | sponge miR-149 | miR-149 | Sun et al. (2020) | |
| circ-FAM53B | ↑ | n = 54 | HO8910, SKOV3, OVCAR3, A2780, iOSE80 | mediates the cellular behavior of OC cells | circ-FAM53B/miRNA-646/VAMP2 and circ-FAM53B/miRNA-647/MDM2 | miRNA-646, miRNA-647 | Sun et al. (2019) |
| circRNA_MYLK | ↑ | n = 46 | SKOV3, OVCAR3, PEO1, 3AO, A2780, CAOV3, HOSEPiCs | contributes to OC malignant progression possibly | regulating microRNA-652 | microRNA-652 | Zhao et al. (2020b) |
| Circ-ABCB10 | ↑ | n = 103 | OVCAR3, UWB1.289, SKOV3, CAOV3, IOSE80 | promotes EOC cell proliferation and reduces apoptosis | negatively regulates miR-1271, miR-1252 and miR-203 | miR-1271, miR-1252 and miR-203 | Chen et al. (2019) |
| circ_0000745 | ↑ | n = 50 | IOSE-80, CoC1, ES-2, SW626, SK-OV-3 | promotes OC cell invasiveness and stemness | miR-3187-3p/ERBB4/PI3K/AKT axis | miR-3187-3p | Wang et al. (2021) |
| circPLEKHM3 | ↓ | n = 10 | A2780, OV90, MDAH2274 | exerts oncogenic effects and affects EMT as well as Taxol resistance | miR-9/BRCA1/DNAJB6/KLF4/AKT1 axis | miR-9 | Zhang et al. (2019a) |
| circ_0007841 | ↑ | n = 43 | IOSE80, SKOV3, OVCAR3 | promotes the expression of MEX3C | circ_0007841/miR-151-3p/MEX3C axis | miR-151-3p | Huang et al. (2021) |
| circCRIM1 | ↑ | n = 154 | OVCAR3, CAOV3 | circCRIM1 and CRIM1 both promote the progression of OC | miR-383-5p/ZEB2 axis | miR-145-5p; miR-383-5p | Du et al. (2021) |
| circWHSC1 | ↑ | n = 92 | CAOV3, OVCAR3 | translocate to peritoneal mesothelial cells and promote peritoneal dissemination | regulating MUC1 and hTERT through sponging miR-145 and miR-1182 | miR-145 and miR-1182 | Zong et al. (2019) |
| hsa_circ_0013958 | ↑ | n = 90 | A2780, OVCAR-3, HOSEpiC | may be involved in the development of OC by affecting epithelial-mesenchymal transition and apoptotic signaling pathways | Pei et al. (2020) | ||
| ciRS-7 | ↑ | n = 40 | SKOV3, A2780, OV 2008, IGROV1, ES-2, HOSE | promotes OC cell growth and metastasis | ciRS-7/miR-641/ZEB1 or ciRS-7/miR-641/MDM2 axis | miR-641 | Zhang et al. (2020b) |
| circ_0000554 | ↑ | n = 40 | HG-SOC, SKOV-3, HO8910, HO8910PM, FTE187 | promotes OC cell growth, invasion and EMT | sponge miR-567 | miR-567 | Wang et al. (2022) |
| circFGFR3 | ↑ | n = 35 | OSE, SKOV3, A2780, OV 2008, IGROV1 | induces EMT thereby promoting OC development | circFGFR3/miR-29a-3p/E2F1 axis | miR-29a-3p | Zhou et al. (2020) |
| Hsa_circ_0009910 | ↑ | n = 50 | SKOV3 | regulates NF-κB and notch pathways | induction of proliferative and motile phenotypes by inhibition of miR-145 | miR-145 | Li et al. (2020) |
| circ9119 | ↓ | n = 50 | SKOV-3, HO-8910, A2780, ES-2, CAOV3, OVCAR3, FTE187 | regulate proliferation and apoptosis | sponge miR-21, targeting PTEN 3′ untranslated region | miR-21 | Gong et al. (2020) |
| circFBXO7 | ↓ | n = 53 | A2780, MDAH2774, OV90, SKOV3, HEK 293 T | promotes OC progression | circFBXO7/miR-96-5p/MTSS1 axis | miR-96-5p | Wu et al. (2022) |
| circ-PGAM1 | ↑ | n = 45 | CAOV3, SKOV3, OVCAR3, ES-2, 293T | circPAGM1 silencing coupled with miR-542-3p overexpression exerted maximal anti-cancer effects | circ-PGAM1/miR-542-3p/CDC5L/PEAK1 | miR-542-3p | Zhang et al. (2020a) |
| circRAB11FIP1 | ↑ | n = 100 | A2789, SKOV3 | associated with autophagy speeds up the proliferation and invasion of EOC | regulates ATG7 and ATG14 by sponging miR-129 | miR-129 | Zhang et al. (2021b) |
“↑” represents upregulation, and “↓” represents downregulation.