TABLE 5.
Effect of CDPDP on liver function tests (LFT’s).
| Groups | ALT (U/L) | AST (U/L) | ALP (U/L) | Bilirubin (mg/ml) | Albumin (mg/dl) |
|---|---|---|---|---|---|
| a) | |||||
| Control | 38.93 ± 0.48a | 25.9 ± 0.34a | 114.8 ± 1.9a | 6.79 ± 0.21a | 6.37 ± 0.24a |
| Negative Control | 97.29 ± 3.41d | 106.1 ± 2.1d | 346.09 ± 7.3d | 11.4 ± 0.19d | 2.69 ± 0.12c |
| Ibuprofen | 43.21 ± 2.43b | 34.0 ± 2.1b | 121.2 ± 3.7b | 7.12 ± 0.66b | 5.97 ± 0.21ab |
| CDPDP (20 mg/kg) | 46.74 ± 3.83c | 37.1 ± 2.4c | 137.3 ± 4.2c | 7.59 ± 0.06c | 5.68 ± 0.13b |
| CDPDP (40 mg/kg) | 43.6 ± 0.46b | 30.9 ± 0.7b | 120.8 ± 2.7b | 7.11 ± 0.29b | 5.99 ± 0.39ab |
| b) Effect of CDPDP on renal function tests (RFT’s) | |||||
| Groups | Urea (mg/dl) | BUN (mg/dl) | Creatinine (mg/dl) | GFR (ml/min) | Protein (mg/dl) |
| Control | 51.4 ± 1.87a | 20.5 ± 0.33a | 1.48 ± 0.09a | 0.43 ± 0.03a | 5.12 ± 0.13a |
| Negative Control | 76.1 ± 2.41d | 50.8 ± 1.9d | 3.01 ± 0.16d | 0.07 ± 0.02e | 1.29 ± 0.11b |
| Ibuprofen | 54.9 ± 2.8b | 26.1 ± 2.4b | 1.63 ± 0.11b | 0.36 ± 0.04ab | 5.09 ± 0.07a |
| CDPDP (20 mg/kg) | 57.8 ± 3.5c | 26.9 ± 2.4c | 1.65 ± 0.10c | 0.34 ± 0.03b | 4.96 ± 0.06ab |
| CDPDP (40 mg/kg) | 55.9 ± 0.43b | 24.6 ± 0.5b | 1.63 ± 0.10b | 0.37 ± 0.03ab | 5.10 ± 0.32a |
Note: ALT, Alanine Aminotransferase/transaminase, AST, aspartate transaminase; ALP, alkaline phosphatase; BUN, blood urea nitrogen; GFR, Glomerular filteration rate. Data values represent Mean ± SD (n = 5). Means with different superscript (a-d) letters in the column are significantly (p < 0.05) different from one another.