TABLE 7.
Predicted pharmacokinetics parameters of CDPDP and Ibuprofen.
| Properties | Parameters | CDPDP | Ibuprofen |
|---|---|---|---|
| Absorption | Water Solubility | −2.59 | −3.36, S a |
| GI b | 81.53 | 94.01 | |
| Log K p (Skin permeation) cm/s | −6.80 | −5.07 | |
| Distribution | BBB a | −0.075 | 0.302, Yes |
| CNS permeation (Log PS) | −2.519 | −1.695 | |
| VD c (human) | −0.168 | −0.877 | |
| Metabolism | CYP1A2 inhibitor | No | No |
| CYP2C9 inhibitor | No | No | |
| CYP2C19 inhibitor | No | No | |
| CYP3A4 inhibitor | No | No | |
| CYP2D6 inhibitor | No | No | |
| Excretion | Total Clearance (log ml/min/kg) | 0.282 | 0.263 |
| Renal OCT2 substrate | Yes | No |
a
Blood-brain barrier.
b
Gastrointestinal.
c
Volume of distribution.