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. 2022 Dec 6;42(12):BSR20220998. doi: 10.1042/BSR20220998

Table 2. Summary of assessment of non-synonymous single nucleotide variants using DeepView - Swiss-PdbViewer.

Non-synonymous SNV Amino acid substitution Change in hydrogen bonds Introduction of steric clash Change in electrostatic potential
rs930531589 H1573Q Lost 2 bonds Gain of 3 hydrogen bonds None
rs1388362405 S1556F Lost 3 bonds Gain of 1 hydrogen bond and 3 steric clashes Change found
rs1461695373 R1555C Lost 5 bonds Gain 2 hydrogen bonds Change found
rs770571074 G1449R Lost 1 bond Gain 3 hydrogen bonds Change found
rs1182970957 C1294G Lost 1 bond No change None
rs1052868434 R1261W Lost 4 bonds Gain 2 hydrogen bonds Change found
rs759915904 G1231R Lost 1 bond Gain 2 hydrogen bonds None
rs1167927296 I996T Lost 1 and Gain 1 Gain 5 hydrogen bonds None
rs776149246 Y991C Lost 1 bond Gain of 5 hydrogen bonds and 1 steric clash None
rs1303994790 A874V No change Gain 2 hydrogen bonds None
rs1314966532 F864L Lost 1 bond Gain 2 hydrogen bonds None
rs868584117 S840C No change Gain 2 hydrogen bonds None
rs183555527 G806R Lost 1 bond Gain 3 hydrogen bonds Change found
rs1244845928 D785H Lost 1 bond Gain of 1 hydrogen bond and 1 steric clashe Change found
rs1181332562 Y775C Lost 1 bond Lost 1 bond None
rs199473690 Y495C Lost 2 bonds Gain 4 hydrogen bonds None
rs199473692 Y495H Lost 2 bonds Gain 4 hydrogen bonds None