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. 2022 Nov 23;13:1034880. doi: 10.3389/fimmu.2022.1034880

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Copyright © 2022 Dankers, Northcott, Bennett, D’Cruz, Sherlock, Gearing, Hertzog, Russ, Miceli, Scheer, Fujishiro, Hayakawa, Ikeda, Morand and Jones

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Type I IFN inhibits DEX-induced GILZ. (A) Daily prednisolone dose in SLE patients with low or high IFN score (GSE88884, n=1756). (B) GILZ expression in PBMC of SLE patients stratified by daily prednisolone dose (GSE88884, n=1756). (C, D) Healthy PBMC were treated with IFNα, DEX or both, after which GILZ mRNA expression was analysed by qPCR (C), and GILZ protein level was analysed by flow cytometry in the same samples (D) GILZ protein level is represented as MFI normalized against the control MFI for each donor. n=9, pooled from three independent experiments. *p<0.05, **p<0.01, ****p<0.0001. #symbol indicates significance of difference from control (untreated) cells, # p<0.05, ## p<0.01, ### p <0.001, ####p<0.0001.