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. 2022 Nov 23;13:1034880. doi: 10.3389/fimmu.2022.1034880

Figure 4.

Figure 4

JAK1/Tyk2 signaling is involved in IFN-mediated inhibition of GILZ. (A) Kidneys from lupus-prone BWF1 mice treated with tofacitinib, DEX or both were analysed for GILZ expression by qPCR (n=9-15). (B–D) Healthy human PBMC were treated with the Jak1/Tyk2 inhibitor tosylate salt (TS) before exposure to IFNα, DEX or both. Expression of pSTAT1 and STAT1 was analysed by western blot (B), and RSAD2 (C) and GILZ (D) by qPCR. n=9-11, pooled from three independent experiments. *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001. ns, Not significant.