Table 2.

Summary of the general principles and criteria of inclusion (registration), and list of coding issues in the 2022 ENCR recommendations on urothelial tumours.

General principles
- These recommendations should be applied to the pure urothelial carcinomas, to urothelial carcinomas with divergent differentiation, and to all other variants.
- Do everything possible to have access to pathological examinations (reports)
- Synchronous urothelial tumors are considered to be all those in the same site that appear in a period of less than or equal to 4 months.
Recommendations for recording urothelial tumors
Criteria for inclusion
- Types of tumors to be included: all invasive and non-invasive urothelial carcinomas including those without histological confirmation.
- Record all synchronous or metachronous urothelial tumors in different sites and laterality.
- Record progressions of the same three-digit sites.
- Do not record recurrences.
- In case of synchronous tumors of the same three-digit site and laterality, record only the most aggressive one
- In case of some synchronous bladder tumors of different subsite with the same level of progression, code as C67.8
- In case of some synchronous urothelial tumors of different three-digit site, code as C67.8.
- Record all the tumors of each side of each three digit site following the previous rules.
- If a patient has been previously diagnosed with an urothelial tumor(s) when resident outside the registration area, record all of them (the ones occurring outside the area of registration and the ones diagnosed being resident in the area of the registry) according to previous rules.
- If a patient has been diagnosed with one or more urothelial tumor(s) before the operation period of the registry, record all their tumors (the ones diagnosed before and the one diagnosed after first date of operation of the registry) according to previous rules.
Coding
- Code according to the most recent version of the International Classification of Diseases for Oncology
- Codes of the most frequent morphological categories when histology is available
- Codes when only cytological examination is available
- Codes when only non-microscopic confirmation is available
- Codes of behavior for unknown level of invasion
- Coding of Grade
- Codes for urothelial carcinomas with other morphological terms
Urothelial carcinoma with squamous cell divergent differentiation
Urothelial carcinoma with an adenocarcinomatous component
Urothelial cell carcinoma subtypes and ICD-O-3 specific code
Urothelial cell carcinoma without specific subtype in ICD-O-3 classification
- Non-urothelial specific carcinomas
- Coding the Basis of Diagnosis
- Coding stage
Recommendations for reporting urothelial tumors
- The Recommendations for recording provide the raw data which can be subsequently analysed.
- Follow IARC/IACR rules to calculate incidence (according to the “International Rules for Multiple Primary Cancers”)
- At the local level, analyze the data recorded and coded with the new Recommendations according to the defined objectives.
- In international projects, define very precisely the inclusion criteria for the data to be submitted and explain in detail how the data will be analyzed for incidence and survival estimates.