Table 2.

Adverse events.

Event	Overall (n = 9)		Cohort 1 (n=4)		Cohort 2 (n=5)
	ALL Grades	Grade ≥ 3	ALL Grades	Grade ≥ 3	ALL Grades	Grade ≥ 3
Any event	8	8	4	3	5	5
Dermatitis	8	7	3	2	5	5
Electrolyte abnormality	7	0	3	2	5	5
Arthralgias	7	2	2	1	5	1
Fatigue	6	0	4	0	2	0
Hepatitis	5	1	2	1	3	0
Fever	4	0	2	0	2	0
Diarrhea	4	2	2	1	2	1
Hypothyroidism	4	0	2	0	2	0
Anemia	4	0	4	0	0	0
Nausea	4	0	4	0	0	0
Burn	3	0	1	0	2	0
Neurotropenia	2	0	1	0	1	0
Thrombocytopenia	2	0	2	0	0	0
Mucositis	2	0	1	0	1	0
Atrial fibrillation	1	0	1	0	0	0
Hypertension	1	0	1	0	0	0
Soft tissue infection	1	0	1	0	0	0
Thrush	1	0	0	0	1	0
Pneumonitis	1	0	1	0	0	0
Adrenal Insufficiency	1	1	0	0	1	1
Edema	1	0	0	0	1	0