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. 2022 Nov 23;13:956907. doi: 10.3389/fimmu.2022.956907

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Copyright © 2022 Chitnis, Kaskow, Case, Hanus, Li, Varghese, Healy, Gauthier, Saraceno, Saxena, Lokhande, Moreira, Zurawski, Roditi, Bergmark, Giovannoni, Torti, Li, Quintana, Clementi, Shailubhai, Weiner and Baecher-Allan

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Surface CD3 and Foralumab dosing (A) Longitudinal PBMCs were stained for CD3 and measured for changes in frequency of CD3+ cells, the intensity of CD3 (MFI) and total T cell counts as compared to baseline (T1) levels. (B) Lineage and differentiation markers in 10ug, 50ug, 250ug and placebo groups. CD4+CD45RA+CD27+ are CD4+ naïve; CD3+CD4-CD8- are DN LAP+; CD8+CD45RA-CD27- CD8 Tem; GZMB+ and PRF1+ in total CD8+ cells is shown. (C) Shows the change with time was estimated using a linear mixed effects model with a fixed categorical effect of time and a random intercept. *p<0.05, **p<0.001). N=6, placebo N=6.