Table 4.

Model performance in the training and validation cohorts.

Model	Training Cohort			Validation Cohort
	NRI	95%CI	P-value	NRI	95%CI	P-value
CBP vs. CP	0.207	0.029-0.385	0.023*	0.303	0.020-0.585	0.036*
CBP vs. BP	0.226	0.038-0.414	0.018*	0.106	-0.084-0.296	0.276
CBP vs. Tan	0.268	0.076-0.460	0.006*	0.313	-0.035-0.660	0.078
	IDI	95%CI	P-value	IDI	95%CI	P-value
CBP vs. CP	0.116	0.042-0.189	0.002*	0.074	0.005-0.147	0.048*
CBP vs. BP	0.141	0.073-0.210	<0.001*	0.045	-0.078-0.770	0.430
CBP vs. Tan	0.128	0.033-0.223	0.008*	0.113	0.003-0.223	0.045*

NRI, net reclassification improvement; CI, confidence interval; IDI, integrated discrimination improvement. CP, clinical parameters model; BP, blood parameters model; CBP, clinical-blood parameters model.

P-value <0.05, P-value were calculated by NRI test and IDI test.