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. 2022 Nov 23;13:1028002. doi: 10.3389/fphar.2022.1028002

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Copyright © 2022 Yuan, Lu, Lian, Zhao, Tang, Xu, Yao and Yu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Nrf2 signaling pathway was activated by AA147 in neurons after cardiac arrest and cardiopulmonary resuscitation (CA/CPR). The brain tissue samples of mice in each group were collected at 1 day after CA/CPR to detect the AA147-dependent activation of Nrf2. (A) Representative images of immunofluorescent staining of Nrf2 (green) presented that AA147 elevated the expression of Nrf2 and increased its nuclear accumulation. Scale bar = 50 μm. (B) The mRNA levels of Nrf2 and (C) HO-1 were examined by qPCR. (D) Western blot analysis of (E) Keap1, (F) Nrf2, and (G) HO-1. Data are displayed as mean ± SD (n = 3). *p < 0.05. **p < 0.01. ***p < 0.001.