Figure 2.

Cluster analysis in untreated LVV patients, revealing the activating IL-17 phenotype with frequent relapse. (A) Cluster heatmap of blood 28 cytokines/chemokines data of the normalized concentration values. (B) Volcano plot displaying significant regulators predicted by Ingenuity Pathway Analysis for Cluster 1 LVV patients in comparison with Cluster 2. The y-axis corresponds to the value of -log₁₀(p-value), and the x-axis displays the activation Z-score value. The red dots represent the predictably activated regulators or the blue dots inhibited. Positive x-values represent probable activation and negative probable inhibition. The Orange horizontal line denotes p-value of 0.05. (C) Ingenuity canonical pathways with the prediction of its activated pathway in Cluster 1 vs. Cluster 2 LVV patients. (D) Kaplan-Meier survival curve regarding relapse free survival rate during the time from the initial diagnosis to the first documented disease relapse. The LVV patients in Cluster 1 (red) demonstrated a higher relapse survival rate (*p < 0.05) than those in Cluster 2 (blue) using Log-rank test. The ticks indicate censored data.