FIGURE 2.

nAChRα3 peptides induced autonomic dysfunction with poor BW gain. Immunizations of nAChRα3 were performed at week 0 and 1 (red frame), and sacrifices were performed at week 4, 8, and 15 (frame of dotted line). Data are expressed as mean ± standard deviation. Asterisks denote statistical significance level (Supplementary Data 2). (A) Serial weight changes, (B) heart rate (HR, /min), and (C) systolic blood pressure (SBP, mmHg) in immunized and control (CTRL) mice. Filled circles represent P1-immunized mice, gray squares represent P2-immunized mice, and open triangles represent CTRL mice.