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. 2022 Nov 23;12:969396. doi: 10.3389/fonc.2022.969396

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Copyright © 2022 García-Vargas, Roque-Reyes, Arroyo-Villegas, Santiago-Negron, Sánchez-Vázquez, Rivera-Torres, Reyes-Meléndez, Cardona-Berdecía, García-Maldonado, Víquez and Martínez-Ferrer

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BAT1 down-regulation increased PC3 and 22RV1 prostate cancer cell and BAT1 overexpression decreased PC3 and 22RV1 prostate cancer cell invasion. (A, B) Representative images of invasive siBAT1 PC3 and 22RV1 cells at a 4X magnification. (C) Relative invasion of siBAT1 PC3 cells caused a significant increase in invasion when compared to control at 12hrs (**P < 0.01) and 24hrs (****P < 0.0001). (D) Relative invasion of siBAT1 22RV1 cells caused a significant increase in invasion when compared to control at 12hrs (*P < 0.05) and 24hrs (***P < 0.001). (E, F) Representative images of invasive BAT1cDNA PC3 and 22RV1 cells at a 4X magnification. (G) Relative invasion of BAT1cDNA PC3 cells caused a significant decrease in invasion when compared to control at 12hrs (****P < 0.0001) and 24hrs (****P < 0.0001). (H) Relative invasion of BAT1cDNA 22RV1 cells caused a significant decrease in invasion when compared to control at 12hrs (***P < 0.001) and 24hrs (***P < 0.001).