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. 2022 Nov 23;12:969396. doi: 10.3389/fonc.2022.969396

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Copyright © 2022 García-Vargas, Roque-Reyes, Arroyo-Villegas, Santiago-Negron, Sánchez-Vázquez, Rivera-Torres, Reyes-Meléndez, Cardona-Berdecía, García-Maldonado, Víquez and Martínez-Ferrer

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BAT1 expression showed changes in genes associated with inflammation, adhesion, and metastasis in PC3 and 22RV1 cells using qRT-PCR. The samples were collected for a period of 24 hours. (A, C) BAT1cDNA PC3 and 22RV1 cells showed a significant decrease in TNF-α expression when compared to siBAT1 (****P < 0.0001). (B, D) BAT1cDNA PC3 and 22RV1 cells showed a significant decrease in IL-6 expression when compared to siBAT1 (**P < 0.01) (***P < 0.001). (E) BAT1cDNA PC3 cells showed a significant decrease in MMP13 expression when compared to siBAT1 (****P < 0.0001). (F) BAT1cDNA 22RV1 cells showed a significant decrease in MMP10 expression when compared to siBAT1 (**P < 0.01). (G) BAT1cDNA 22RV1 cells showed a significant increase in TIMP2 expression when compared to siBAT1 (***P < 0.001).