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. 2022 Nov 23;12:969396. doi: 10.3389/fonc.2022.969396

Figure 5.

Figure 5

In vivo expression of BAT1, Ki67, TNF-α, IL-6, and MMP10. All of the samples were collected for a period of 24 hours. (A) Representative images of immunohistochemical staining BAT1 expression in mice prostate tumors previously injected with 22RV1 cells, BAT1cDNA 22RV1 cells, or shBAT1 22RV1 cells at a 20X (50μm) or 60X magnification (10μm) magnification. (B) Quantification mice prostate tumors obtained from BAT1cDNA mice prostate tumors showed a significant increase in BAT1 expression using immunohistochemistry when compared to control (*P < 0.05) and shBAT1 (**P < 0.01). (C) shBAT1 (**P < 0.01) and BAT1cDNA (*P < 0.05) tumors showed a significant decrease in Ki67 expression when compared to control. (D) shBAT1 tumors showed a significant increase in TNF-α expression when compared to control and BAT1cDNA (*P < 0.05). (E) shBAT1 tumors showed a significant increase in IL-6 expression when compared to control and BAT1cDNA mice prostate tumors (*P < 0.05). (F) shBAT1 tumors showed a significant increase in MMP10 expression when compared to control (*P < 0.05).