Table 1.
Alteration of BAT1 expression showed changes in genes associated with inflammation, adhesion and metastasis in PC3 and 22RV1 cells using qRT-PCR.
| Cell Line Transfected | Gene | Function | Fold Change |
|---|---|---|---|
| PC3 BAT1cDNA vs PC3 siBAT1 | TNF-α | Involved in systemic inflammation | -1.35 |
| PC3 BAT1cDNA vs PC3 siBAT1 | IL-6 | Pro-inflammatory cytokine | -0.92 |
| PC3 BAT1cDNA vs PC3 siBAT1 | MMP13 | Involved in cancer migration | -6.25 |
| 22RV1 BAT1cDNA vs 22RV1 siBAT1 | TNF-α | Involved in systemic inflammation | -4.34 |
| 22RV1 BAT1cDNA vs 22RV1 siBAT1 | IL-6 | Pro-inflammatory cytokine | -9.09 |
| 22RV1 BAT1cDNA vs 22RV1 siBAT1 | TIMP2 | Directly suppress the proliferation of endothelial cells | 4.33 |
| 22RV1 BAT1cDNA vs 22RV1 siBAT1 | MMP10 | Involved in cancer migration | -4.00 |