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. 2022 Nov 23;12:1004751. doi: 10.3389/fcimb.2022.1004751

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Copyright © 2022 Yao, Mao, Xu, Qiu, Zhou, Wang, Pang, Chen, Cao, Bao, Bao, Guo, Hu, Zhang and Cui

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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VSP inhibited the levels of UP Ia and UP Ib in the mouse bladder. (A), Representative costained images with UP Ia, UP Ib, and DAPI captured the bladder tissue of the UPEC CFT073-infected C3H/HeN mice. Yellow rectangle: higher magnification view of the selected area (parallel sections, the green signals represent UP Ia, the red signals represent UP Ib, the blue signals represent DAPI, scale bar = 50 μm); (B), Representative scatterplots for the UPIa and UPIb expression levels from the bladder tissue of the C3H/HeN mice infected with UPEC CFT073. (C, D), Statistical analysis of the UPIa- and UPIb-positive cells in the entire cross-sectional tissue region of the mouse bladder. Quantitatively, the percentage of cells expressing UPIa (UPIa/DAPI) and UPIb (UPIb/DAPI). n=3 mice per group, compared with the control group: ^# p < 0.05. The results were determined by Wilcoxon rank-sum test.