TABLE 1.

Binding affinity constants for the α_2A-, α_2B-, and α_2A-adrenoceptors of clonidine and the antagonists used in the present study. The nanomoles (and their equivalents in μg) spinally administered in the current experiments are also shown.

	Affinity values (pK i or pK D) for α2-adrenoceptor subtypes			Nanomoles (nmol) and their equivalents in μg used in the present study
	α2A	α2B	α2C
Clonidine a	7.2	7.2	6.9	0.1 nmol (0.02 μg)
				1.0 nmol (0.2 μg)
				10.0 nmol (2.0 μg)
BRL 44408 b	7.2	5.4	6.2	0.1 nmol (0.22 μg)
				1.0 nmol (2.2 μg)
Imiloxan b	5.9	6.5	6.3	10 nmol (2.44 μg)
JP-1302 b	5.3	5.1	6.9	1 nmol (0.37 μg)
				10 nmol (3.7 μg)

All data are given as pK _i.

^a (Jasper et al., 1998) or pK _D.

^b (Proudman et al., 2022) values at human receptors.